منابع مشابه
Clinical pharmacology of propranolol.
ONE OF THE more significant advances in cardiovascular therapeutics in the past decade has been the introduction of 3-adrenergic blocking drugs. This review is prompted by the expanding indications and more widespread use of this group of drugs. Although several compounds have been developed, propranolol was the first to gain wide acceptance and remains the only one available for general use in...
متن کاملClinical Pharmacology of Propranolol By ALAN
ONE OF THE more significant advances in cardiovascular therapeutics in the past decade has been the introduction of 3-adrenergic blocking drugs. This review is prompted by the expanding indications and more widespread use of this group of drugs. Although several compounds have been developed, propranolol was the first to gain wide acceptance and remains the only one available for general use in...
متن کاملCardiovascular pharmacology of propranolol in man.
The success of propranolol in treating the symptoms of angina pectoris has raised questions about the effects of beta-adrenergic blockade on the hemodynamic functions, myocardial mechanics, energetics, and metabolic functions. Five milligrams of propranolol was given intravenously to 27 human subjects, 18 with and nine without angiographically proven coronary atherosclerosis. The drug produced ...
متن کاملPharmacology of propranolol in patients with cirrhosis and portal hypertension.
Ten patients with cirrhosis and protal hypertension received an initial 20 mg oral test dose of propranolol and subsequently 160 mg of a slow release preparation, orally, each day for seven days. Protein binding, serial plasma propranolol concentrations and effects on heart rate were studied. Protein binding was slightly reduced (mean 85%, range 78.9-88.1%) compared with four normals (mean 87.9...
متن کاملClinical experiences with propranolol.
ADRENERGIC beta-receptors are responsible for the cardiac effects of the sympathetic nervous system (Ahlquist, 1948). Pronethalol (Black and Stephenson, 1962) first proved to be an effective beta-receptor blocking agent with little sympathomimetic activity. Limited clinical trials suggested that pronethalol was of value in angina (Dornhorst and Robinson, 1962; Alleyne and colleagues, 1963; Barn...
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ژورنال
عنوان ژورنال: Circulation
سال: 1975
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.52.1.6